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Darvocet is a brand name for a prescription painkiller that combined the opioid drug propoxyphene with the non-opioid pain reliever acetaminophen. The medication is no longer available in the U.S. and many other countries due to serious safety concerns. 

Why Darvocet was discontinued

Serious heart risks: New data revealed that propoxyphene could cause significant changes to the electrical activity of the heart, even at therapeutic doses. These effects could lead to serious abnormal heart rhythms, which the FDA concluded outweighed the drug's benefits for pain relief.

Overdose risk: Darvocet carried a high risk of overdose, which could be fatal, especially when combined with alcohol or other central nervous system depressants. This was a concern for patients with a history of emotional or suicidal tendencies.

Withdrawal: Propoxyphene was habit-forming and could cause physical and psychological dependence. Abruptly stopping the medication could cause withdrawal symptoms.

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